Macrolide resistance in Treponema pallidum in the United States and Ireland.
نویسندگان
چکیده
From the Departments of Medicine (S.A.L., C.G., B.J.M., P.S., C.M.M.) and Neurology (C.M.M.), University of Washington, Seattle; St. James Hospital, Dublin (S.H., F.M.); the San Francisco Department of Health, San Francisco (J.E., S.J.M., J.D.K.); the Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta (S.J.M.); and the Department of Medicine, Johns Hopkins University, Baltimore (A.M.R.). Address reprint requests to Dr. Lukehart at the Department of Medicine, Box 359779, Harborview Medical Center, 325 9th Ave., Seattle, WA 98104, or at [email protected].
منابع مشابه
Azithromycin resistance in Treponema pallidum.
PURPOSE OF REVIEW Although the recommended treatment for syphilis is penicillin, azithromycin has been used as an alternative. We discuss azithromycin-related treatment failures and resistance in Treponema pallidum, and propose ways to meet the resulting clinical and public health challenges. RECENT FINDINGS Azithromycin treatment failures in syphilis were first noted in San Francisco in 2002...
متن کاملHigh prevalence of macrolide resistant Treponema pallidum strains in a London centre.
OBJECTIVES Macrolide resistant Treponema pallidum strains, caused by mutations in the 23S ribosomal RNA (23S rRNA) gene, are widespread and increasingly prevalent. The authors aimed to establish the strain types of T pallidum isolated from patients in a London sexual health centre and to determine the frequency of macrolide resistance. METHODS T pallidum DNA from blood and ulcer samples were ...
متن کاملPrevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009.
BACKGROUND The 23S rRNA A2058G point mutation in Treponema pallidum is associated with macrolide antibiotic treatment failure. Its prevalence and potential association with a molecular subtype within the United States are unknown. METHODS During 2007 to 2009, 11 clinics across the United States sent samples from genital ulcers to the Centers for Disease Control and Prevention. Molecular techn...
متن کاملDetection of the A2058G and A2059G 23S rRNA gene point mutations associated with azithromycin resistance in Treponema pallidum by use of a TaqMan real-time multiplex PCR assay.
Macrolide treatment failure in syphilis patients is associated with a single point mutation (either A2058G or A2059G) in both copies of the 23S rRNA gene in Treponema pallidum strains. The conventional method for the detection of both point mutations uses nested PCR combined with restriction enzyme digestions, which is laborious and time-consuming. We initially developed a TaqMan-based real-tim...
متن کاملMacrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains
BACKGROUND High rates of 23S rDNA mutations implicated in macrolide resistance have been identified in Treponema pallidum samples from syphilis patients in many countries. Nonetheless, some clinicians have been reluctant to abandon azithromycin as a treatment for syphilis, citing the lack of a causal association between these mutations and clinical evidence of drug resistance. Although azithrom...
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عنوان ژورنال:
- The New England journal of medicine
دوره 351 2 شماره
صفحات -
تاریخ انتشار 2004